LCC Engineering & Trading GmbH
Is a dedicated family owned company and in chromatography business since 1995.
Our clients are professionals that analyse, synthesize, separate and purify complex molecules and particles. It is our job to assist with suitable tools and technical competency so that they can perform their work effectively, efficiently and competitively.
From the sixties to about the year 2000 many chromatographers pioneered new applications and methods so as to advance the industry further. Some did it as employees in large companies, others did ist as researchers in Universities in combination to get a master or PhD. Many started a new company focussed on selling their new specialty products. There were permanently about 60 to 80 companies woldwide including us that assistsed the pioneering user (Drug discoverers, medicinal chemist) involved in creating new APIs and unique production processes. It was a win – win process for all parties. On one side there were the entrepreneurs and inventors with new materials, methods and unique know How. On the other side of the equation there were the drug discoverers, the medicinal chemists process researcher and developers, the biotechnologist and the analytical chemists, -in short the clients who were permanently searching for new and better tools to advance the separation/purification sector and to create IPR protectable value for the share holders. During the 90ties NMR, MS, AA and others detector systems emerged to be used in combination with Chromatography. Five very large technology suppliers saw a great future in these technologies and so they went public to raise the funds that were required to develop the software driven technologies.
By end nienties the large public companies offered the were They had the freedom to search for technology suppliers with new innovative tool that helped them to create new patentable pure compounds or unique methods. The created new with developing, manufacturing, servicing highly specialised equipment and tools. Some of them were also used to expand patentlive from 25 to 27 years. With such patent extension strategies pharmaceutical companies could increase their revenue dramatically.
At around 2000 the larger publicly owned chromatography enterprise required large summs of funds to develop LIMS System and MS technology. Those companies could convice the large pharmaceutical companies to procure their software and euipment and to finance their technology development. The market started to devide in five large public companies (Waters, Agilent, Thermo, Shimatzu and Sciex) and about 70 medium to small players. In the past the small and highly innovative companies were vital contributors to innovation in drug discovery, optimisation and process R & D. Over the years it was a win-win situation for all parties. With the emergence of the LC-MS and NMR technologies cost of drug R & D started to grow exponentially. (1995 = 450 Mio. 2015 = 4.8 Mia.). Despite the growing cost Pharmaceutical companies also expanded their operation and revenue and became less and less dependent on Banks. In the USA Venture capital had a long tradition in helping to finance growth of new life science enterprises. In the late nientie early 2000 the banks promoted shadows bankers, the Venture Capitalists to avoid loosing their researching life science clients. They could convince the researching life science cconglomerates to outsource the high risk elements that is drug diccovery and optimisation from the balance sheets through VC. Novartis was the first Pharmaceutical company that introduced a Venture Capital fund
and solution providing of liquid chromatography technology to chromatography professionals world wide.
Company Location & Admin Details
LCC Engineering & Trading GmbH
Registration No. CH-240.4.000.141-9, Reg Date: 29.8.1997
Vat. No. ‘CHE 108.663.073 MWST’, IBAN:’CH94 0833 4000 0S33 1582 B’
Historical Evolution of the Industry
The chromatography and bio-chromatography supplier market comprises of five to seven large multinational system suppliers, two large publicly owned sales organisation and approx. 70 material and component manufacturing specialists. Many of them are family owned enterprises with little staff turnover and in business for many years.
The user market comprises analytical laboratories and production sites in researching parmeceutical , generic pharmaceutical, phyto-chemical, agro-chemical, fine-chemical, food technology and nutrition, environmental, forensic, cosmetics and university labs. Chromatography is also used in the production of highly pure and chiral compounds.
Chomatography data users such as registration authorities and courts demand that all molecules are being qualyfied and quantified at a competitive cost. Production manager consider use of chromatography only if the process results in purer compounds, at higher yield and for lower cost than recrystalisation.
To compete successfuly life science companies must permanantly create new unique molecules or blends that can be IPR protected, that show better performace properties or have lower production costs. If no new Pharmaceutical Active Ingredients (API) are being developed survivel of the industry is endeangered.
To assure continuation of progress in chromatography innovative manufacturer have developed over the past 50 years many novel and dramaticaly improved tools and uniqe materials. Today we have more than 4000 different materials with different chemistries and properties. This huge diversity has created many new jobs and solutions to solve separation and purification problems.
In recent years there is a trend to force chromatographers to procure commodity materials and to simplify methods. This is in contradiction with todays successful strategies to fight competition. It also demotivates chromatographers and results in decline of professional know how and skills.
As independent operators we provide a range of services to assure continuation of progress in chromatography!
- Broad range of high quality chromatography products from globally active manufacturers. (With many supply partners we have mutual sole distributorships with clearly defined territories)
- Experienced technical support team
- New product design and development
- Confidentiality guaranteed
- Column selection guidance
- Budget bridging
- Troubleshooting advice.
- Free application searches
- Worlds largest HPLC applications data base
- Free method strategy consultancy
- Method development and optimisation service
- Column validation service
- Samples chromatograms from a wide range of columns
- Wide range of chromatography materials, equipment and plants
- Unrivaled product knowledge to provide neutral advise
- Extensive range of column dimensions
- Customer supplied packing
- Batch reservation service
- Unrivalled experience in the manufacture of superior quality columns from microbore to preparative scale dimensions.
Through our network of business partners we cover >95% of the world’s leading brands. If we cannot supply your specific HPLC column requirement we will be pleased to recommend an alternative.
Many clients, especially those in Universities and large companies are forced to consume their annual budgets before the end of every year. This forces the clients to start buying products they dont need immediately.. We help to solve this problem by selling a product package in the old year so that they can consume it in the first half of the coming year when ever they want to use it.
Column Lifetime and Stability
The quality and aqueous stability of HPLC silica is continuesly improved. However, the inherent chemical instability of bonded phases at low pH and the dissolution of silicas at high pH remains an underlying problem. We are able to advise on recommended column usage conditions, column protection and storage.
Advice on impurity peaks, sample cleanliness, scale-up and many other HPLC column issues is readily available.
The recent development of numerous new ranges of HPLC columns has complicated the chromatographers choice. Our scientists will be very happy to discuss your individual needs and recommend a column. We maintain a wide-ranging library of general and manufacturers’ literature. Our practical experience in manufacturing and evaluating our own columns, together with those of suppliers and competitors, gives us a wide-ranging knowledge of column selectivity. We are similarly able to advise on column reproducibility and validation criteria.
Applications Data Base
We have access to worlds largest reference data base of HPLC applications and columns. It currently contains applications involving over 40,000 analyts separated on a wide range of column materials. Approximately 2000 of these applications are related to chiral analyses.
Applications cover a broad range of compound areas, including:-
a) Biochemical (e.g. peptides and proteins)
c) Ion analysis
e) Pesticides and environmental
i )Medical and Radio-pharmaceutical
Searches can be performed for an individual compound, a mixture of components or a specific column. This proves useful in aiding selection of a suitable column for a particular analysis or in finding alternative columns for a given assay.
Where suitable, our technical staff are able to discuss and recommend method strategies for customers using the application data base. If appropriate, we will practically develop and optimize the most suitable HPLC method.
Column Screening Service
As the availability of HPLC silicas increases, selection of the optimum column for a particular method is becoming an increasingly onerous task. We maintain an extensive HPLC column library and are well placed to evaluate and advise on selection of the optimum phase.
Method Development and Optimisation Service
Once an HPLC phase has been chosen the optimum column configuration and HPLC conditions need to be selected for required efficiency, speed of analysis, relevant eluent pH, temperature and other practical parameters. We offer both advice and practical support in method development and optimisation procedures.
Column Validation Service
An approved method needs to be checked for robustness and reproducibility. We will evaluate the performance of a method over a period of time. We will also validate the performance of columns manufactured from different batches of the same material.
Wide Range of Materials and Column Dimensions
Please contact us if the packing or column dimensions you require are not listed or standard. We have highly experienced column manufacturing partners that are able to supply columns that fit your specification. Additional column hardware geometries are also available.
Customer Supplied Packings
In addition to the manufacture of columns containing commercially available HPLC packings, We routinely manufacture columns of any specified dimension from customer supplied materials. We will be pleased to sign a confidentiality agreement if required.
Batch Reservation Service
We recognises that column to column reproducibility is of utmost importance. Column manufacture is always optimised on the largest available batches of silica.
However, for particularly searching applications, we also offer a free batch reservation service which completely eliminates batch related reproducibility concerns. Based on your projected column usage (large or small), we will reserve the quantity of silica you require and pack columns as and when they are required.
Customer enabled equipment design
Although our plant and equipment design is extremely sturdy (compare the weight/price of our pumps with the weight/price of competitive pumps) and easy to handle we cant promise that you never will experience any break down. However, when ever possible we design our pumps in such a way that with a possible equipment breakdown you, our clients will be able to quickly and easily find and exchange the faulty components and without use of complex mechanical and electronic tools. This enable us to get you back in operation in the shortest possible time anywhere on this globe.
Joint equipment development
Over the years we have pioneered together with clients and universities a number of new technologies with an aim to advance efficacy, efficiency and effectiveness of liquid chromatography. Don’t hesitate to discuss with us your new ideas or requirements